Androgenic Facial Masculinization: Dose, Timeline, Mechanism
Androgenic facial masculinization occurs through three primary pathways: androgen receptor-mediated osteoblast proliferation in the mandible and maxilla, DHT-driven chondrocyte hypertrophy in nasal and auricular cartilage, and increased sebaceous gland activity with periorbital fat redistribution. The dose-response curve is nonlinear—supraphysiological testosterone (500+ mg weekly) yields measurably more pronounced mandibular widening and brow ridge prominence than replacement … Read more